Endocrine Abstracts

Communication between microbiota and the host is critical to sustaining the vital functions of the healthy host, and disruptions of this homeostatic coexistence are associated with a range of diseases including obesity and T2D. Microbiota-derived metabolites act both as nutrients and as messenger molecules to shape host pathophysiology. Succinate, which has the distinction of being produced by both the host and microbiota, is quickly becoming a poster child for these metabolit...

Introduction: Bariatric surgery is an effective therapy for patients with type 2 diabetes mellitus (T2D). Many mechanisms have been proposed for its metabolic benefits, such as caloric restriction, weight loss, increased secretion of gut hormones like glucagon-like peptide 1 (GLP-1) and 2 (GLP-2), bile acid diversion, decrease of pancreatic and hepatic fat deposits and changes in gut microbiome.Aims: Evaluate changes after surgery in gut microbiome profi...

Introduction: In vitro and animal studies have suggested that changes in the secretion of ghrelin, PYY, GLP-1, GLP-2 can influence bone metabolism. An increase in osteoblastic differentiation has been observed after the administration of ghrelin and GLP-1. GLP-2 has been associated with a decrease in bone resorption and PYY inversely with markers of bone formation.Objective: To analyze the association of gastrointestinal hormones with changes in...